For example, circRNA_000200 and circRNA_104308 could regulate the expression of suppressor of cytokine signalling 3 (SOCS3), follistatin (FST), TGFB1, TGF beta receptor 2 (TGFBR2), Fos proto-oncogene, AP-1 transcription factor subunit (FOS), AVR1B, cyclin D2 (CCND2) and Kruppel like factor 2 (KLF2) by sponging miR-185-5p to participate in the pathways of hsa:04,380: Osteoclast differentiation, hsa:04,350: TGF-beta signalling pathway, hsa04068: FoxO signalling pathway or hsa05142: Chagas disease (American trypanosomiasis). The gene discussed is TGFBR2; the disease is Chagas disease.