CircRNA_100086 could regulate the expression of MAPK1 and TGFBR2 by sponging miR-509-3p to participate in the pathways of hsa:04,350: TGF-beta signalling pathway, hsa04068: FoxO signalling pathway, hsa05142: Chagas disease (American trypanosomiasis) and hsa:04,380: Osteoclast differentiation. The gene discussed is TGFBR2; the disease is American trypanosomiasis.