The previous research showed that β-Catenin, which is involved in the pathogenesis and progression of malignant tumors, especially cancer stem cells, was upregulated and activated in EGFR-sensitizing mutant cells, and more in EGFR-mutant cells bearing T790M than in wild-type EGFR cells, and suggested that a cooperative association between β-catenin and EGFR-sensitizing mutations or with T790M plays a significant role in lung tumorigenesis [41]. This evidence concerns the gene EGFR and cancer.