Our work indicated that circPOLR2A functioned in cRCC by enhancing the ubiquitination degradation of PEBP1 mediated by the ubiquitin E3 ligase, UBE3C, and revealed crosstalk between circPOLR2A and the m6A reader, YTHDF2. The gene discussed is YTHDF2; the disease is chromophobe renal cell carcinoma.