Our work indicated that circPOLR2A functioned in cRCC by enhancing the ubiquitination degradation of PEBP1 mediated by the ubiquitin E3 ligase, UBE3C, and revealed crosstalk between circPOLR2A and the m6A reader, YTHDF2. Here, PEBP1 is linked to chromophobe renal cell carcinoma.