Since Cdt2 facilitates degradation of p21 and Set 8 [8, 14], we next checked the level of p21 and Set 8 upon miR-34a expression in HR HPV positive cervical cancer cells and found that Cdt2 destabilization stabilizes both p21 and Set 8 protein level significantly (Fig. 1C and D). The gene discussed is DTL; the disease is cervical cancer.