TSC1 and Werner syndrome: This includes, for instance, mitochondrial DNA (mtDNA) mutator mice, irradiated mice, mice featuring diet-induced obesity, telomere-dysfunctional mice, mouse models with persistent expression of Wnt1, mouse models with conditional deletion of Tsc1 or mouse models of rare genetic syndromes termed progerias (Werner syndrome (WS), Hutchinson-Gilford syndrome (HGPS)).