This includes, for instance, mitochondrial DNA (mtDNA) mutator mice, irradiated mice, mice featuring diet-induced obesity, telomere-dysfunctional mice, mouse models with persistent expression of Wnt1, mouse models with conditional deletion of Tsc1 or mouse models of rare genetic syndromes termed progerias (Werner syndrome (WS), Hutchinson-Gilford syndrome (HGPS)). The gene discussed is TSC1; the disease is Hutchinson-Gilford progeria syndrome.