The genes validated as targets of miR-365b included EPN1, H2AFY, PI3KR3 and VGLL4, in which all have been reported as players in tumor biology36,37, and interestingly both VGLL4 and EPN1 were shown to be involved in regulation of Wnt-signaling38,39, a pathway that is dysregulated in MM40. Here, MACROH2A1 is linked to neoplasm.