The exceptions included CheckMate 057 (NSCLC), where patients identified as PD-L1–positive at cutoffs of ≥1% and ≥5% using AI-powered scoring were associated with a lower ORR (21.1% and 25.5%) compared with manual scoring (28.3% and 32.5%) (Fig. 5). Here, CD274 is linked to non-small cell lung carcinoma.