CD274 and non-small cell lung carcinoma: In general, the majority of OR point estimates suggested a slight increase in the association between ORR and patients identified as PD-L1–positive using AI-powered scoring compared with manual scoring in four out of five studies (NSCLC [CheckMate 057], UC [CheckMate 275], MEL [CheckMate 067 NIVO + IPI arm], and SCCHN [CheckMate 141]) at the 1% cutoff and in four out of six studies (NSCLC [CheckMate 026], UC [CheckMate 275], MEL [CheckMate 067 NIVO arm], and SCCHN [CheckMate 141]) at the 5% cutoff.