Conversely, in CheckMate 141 (SCCHN), there was a slight increase in ORR in patients identified as PD-L1–positive using AI-powered scoring (20.0% and 25.0%) compared with manual scoring (16.7% and 21.2%) at cutoffs of ≥1% and ≥5% (Fig. 5). Here, CD274 is linked to head and neck squamous cell carcinoma.