Interestingly, In drug stimulation experiment, after the addition of the chemotherapy drug Ara-C, compared with the untreated groups, the expression of RFC4 was further attenuated in Nrf2-overexpressing AML cells (P < 0.05, Fig. 4C), whereas that of RFC4 was further increased in Nrf2-silenced AML cells (P < 0.05, Fig. 4D). This evidence concerns the gene NFE2L2 and acute myeloid leukemia.