However, the roles of many vital molecules (e.g., GPR182, ADH4, miR-4746-5p, miR-5589-3p, CNV of CCNA1 and PCCA, ARID1A mutation, etc.)in HCC are still unclear, and further cell and animal experiments to reveal their underlying mechanism is warranted. Here, PCCA is linked to hepatocellular carcinoma.