However, the roles of many vital molecules (e.g., GPR182, ADH4, miR-4746-5p, miR-5589-3p, CNV of CCNA1 and PCCA, ARID1A mutation, etc.)in HCC are still unclear, and further cell and animal experiments to reveal their underlying mechanism is warranted. This evidence concerns the gene CCNA1 and hepatocellular carcinoma.