A similar degree of hypoinsulinemia, hyperketonemia, hyperglycemia, hypertriglyceridemia and reduced body weight was observed in DT-treated RIP-DTR; S100a9-/- mice compared to DT-treated RIP-DTR; S100a9+/+ controls (Supplementary Fig. 1A–E). Here, S100A9 is linked to hypertriglyceridemia.