SLITRK5 and obsessive-compulsive disorder: Previous studies have shown that SLITRK5 acts as a co-receptor for TrkB that orchestrates brain-derived neurotrophic factor (BDNF)-TrkB-dependent trafficking and signaling13, and that an obsessive-compulsive disorder (OCD)-associated SLITRK5 missense variant impairs SLITRK5 binding to TrkB26.