Since BRAFV600E and loss of p53 cooperate to form melanomas, and because BRAFV600E causes tetraploidy as seen in our in vivo and in vitro models, we were interested in understanding whether BRAFV600E-generated tetraploid cells serve as intermediates in melanomagenesis in our zebrafish model, potentially as cells of origin. This evidence concerns the gene TP53 and melanoma.