KCNQ2 and neurodegenerative disease: In addition, beyond normative aging, sleep disruption is especially pervasive in neurodegenerative diseases, such as Alzheimer’s disease.4 The activated pathway of Hcrt neurons-to-basal forebrain increases acetylcholine release and activity of cortical neurons, affecting cognitive function.5 Besides, the amyloid-β-induced hyperexcitation is identified to be correlated with the expression of Kcnq2/3 in hippocampal neurons.5 The hyperexcitability of Hcrt neurons in aged mice of this study may provide a theoretical basis for neurodegenerative diseases-associated sleep instability.