Moreover, administration of Kcnq2/3-selective activator, flupirtine, significantly inhibited spontaneous firing activities in Hcrt neurons and increased the sleep stability in aged mice.1 These findings may provide a possible strategy to improve aging-related sleep disorders, and identifying more specific pharmacological targets acting on Hcrt neurons may shed light on conquering the possible unanticipated side effects of Hcrt receptor antagonists. Here, HCRT is linked to sleep disorder.