Among the CpGs and genes differentially methylated in both BCH and TCGA, methylation levels of TAPBP (encompassing several differentially methylated CpGs) were significantly associated with RNA expression of this gene, concurred with other genome-wide deregulations to yield a high multi-OMICs driver potential and were significantly correlated with melanoma-specific survival. The gene discussed is TAPBP; the disease is melanoma.