Recently, TCGA-cutaneous melanoma patients have been classified into four molecular mutation subgroups: 1—BRAF, associated with younger patients and with BRAF and MITF amplifications; 2—RAS, associated with MAPK activation and AKT3 overexpression; 3—NF1, associated with older patients and higher mutation burden; 4—The triple negative (TN), which is wild-type for BRAF, RAS, and NF-1, lacks the UV mutational signature and has higher copy number and complex rearrangements9. The gene discussed is MITF; the disease is cutaneous melanoma.