Out of the 458 CpGs from 169 genes significantly overlapping (p = 2.3e−109 and p = 3.71e−29, respectively) between BCH and TCGA cohorts (Supplementary Data 18, Fig. 4a), 6 CpGs (HOXC9, KCNQ1DN and MGMT genes) were hypermethylated and 30 CpGs (TAPBP, ERICH3, FINL2, ZNF732, SLC6A18, MFSD13A, SLFN12L, and IFNLR1 genes) were hypomethylated in both BCH and TCGA, considering CpGs with absolute effect sizes ≥10% and with no significant enrichment in SNPs (Supplementary Fig. 1b, c). This evidence concerns the gene SLC6A18 and choreatic disease.