These pathways constituted of differentially methylated genes implicated in immune system regulation: hematopoietic cell lineage, allograft rejection, graft-versus-host disease, intestinal immune network for IgA production, antigen-processing presentation, inflammatory bowel disease, and relatedly, autoimmune diseases, such as type 1 diabetes mellitus, autoimmune thyroid disease, systemic lupus erythematosus and rheumatoid arthritis (Fig. 3c). Here, CD79A is linked to diabetes mellitus.