Consensus driver30 and secondary driver genes have been recently described in cutaneous melanoma31, among which several were differentially methylated in UV-mutant versus non UV-mutant cutaneous melanomas patients in our analysis (COL5A1, DACH1, MECOM, PTEN, TP53, BRD9, BCL7, SPRED1, SIGLEC12, and SIGLEC10) (Supplementary Data 2–6). The gene discussed is SPRED1; the disease is cutaneous melanoma.