Despite the evidence that ApoA1 has an advantageous role in stabilization of EC maintenance, the effects of this protein on the ALS-damaged CNS endothelium in both patients (Garbuzova-Davis et al., 2012) and an animal model of disease (Garbuzova-Davis et al., 2007a,b) are unknown. Here, APOA1 is linked to amyotrophic lateral sclerosis.