ApoA1’s beneficial role in EC survival, identified in the current study, along with secretion of angiogenic factors such as VEGF-A and angiogenin-1, by hBM-EPCs (Garbuzova-Davis et al., 2019a), are potential mechanisms for endothelium repair via cell therapy in ALS. The gene discussed is VEGFA; the disease is amyotrophic lateral sclerosis.