The biological underpinnings of the severity model consisted of coregulated plasma and single-cell proteomic elements that progressed with COVID-19 severity, including the inflammatory cytokine response to SARS-CoV-2, the mobilization of the RAS and primary hemostasis system, and the dysregulation of the JAK/STAT, NF-κB, and MAPK/mTOR immune signaling responses. The gene discussed is MTOR; the disease is COVID-19.