Both single-cell immune response (endogenous signaling and signaling response to IFNα/IL-2/IL-4/IL-6 and LPS/CL097; factor 10) and plasma proteome (factor 3) data contributed strongly to the variance observed in our samples (Figure S3B) and were significantly associated with COVID-19 severity (Figure S3C). This evidence concerns the gene IL4 and COVID-19.