CD40 and neoplasm: TAM- and Treg-generated IL-10 suppresses cDC production of IL-12, a costimulatory molecule necessary to mount an adaptive immune response.32 cDCs are also subject to increasing apoptosis secondary to increased levels of IL-6.60 Combination therapy with a CD40 agonist (a stimulatory ligand for T-cell activation) and FLT3L restored cDC abundance, improved tumor infiltration, and resulted in superior control of tumor outgrowth in a preclinical model.61