CXCR2 and neoplasm: Genetic ablation of CXCR2, a chemokine receptor found predominantly on Gr-MDSCs, led to increased T-cell infiltration into the tumor stroma.56 In an orthotopic model, inhibition of MDSCs via CXCR2 blockade led to decreased MDSCs within the TME, decreased fibrosis, and acted synergistically with ICB.57