APOC3 and Insulin resistance: Among the top ranked proteins, we could easily notice angiotensinogen (AGT), which was previously associated with IS condition [19]; paraoxonase-1 (PON1), that has been found to down-regulate insulin resistance in mice [20]; apolipoprotein-3 (APOC3), highly associated with IR [21]; and increasing α2-HS-glycoprotein (AHSG), which is indeed tightly associated with IS [22].