CD8A and neoplasm: In the TCGA cohort (Fig. 8A), the population of protumor immune cells, especially regulatory T (Treg) cells, macrophages, and other immune cells, such as CD8 + T cells, T helper (Th) cells (Tfh and Th2 cells), tumor-infiltrating lymphocytes (TILs), and B cells, was higher in the high-risk group than in the low-risk group.