Among them, 6 genes (CYCS, IL1A, IL6, PRKACA, NLRP2, and NLRP7) were downregulated, and 21 other genes (BAK1, BAX, CASP1, CASP3, CASP4, CHMP2A, CHMP4A, CHMP6, GSDMD, GSDME, HMGB1, IL18, IRF2, TP53, AIM2, CASP6, CASP9, NOD1, NOD2, SCAF11, and PYCARD) were enriched in the glioma group. The gene discussed is CASP4; the disease is central nervous system cancer.