Among them, 6 genes (CYCS, IL1A, IL6, PRKACA, NLRP2, and NLRP7) were downregulated, and 21 other genes (BAK1, BAX, CASP1, CASP3, CASP4, CHMP2A, CHMP4A, CHMP6, GSDMD, GSDME, HMGB1, IL18, IRF2, TP53, AIM2, CASP6, CASP9, NOD1, NOD2, SCAF11, and PYCARD) were enriched in the glioma group. Here, CASP6 is linked to central nervous system cancer.