Circulating CD4+ T follicular helper (Tfh) cell responses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccinated SARS-CoV-2 experienced rheumatoid arthritis using methotrexate (RA-MTX) and multiple sclerosis using ocrelizumab (MS-OCR) patients. The gene discussed is CD4; the disease is rheumatoid arthritis.