Overall, these data indicate that immunosuppressants MTX and OCR dampen a rise in total CD4+ cTfh cell numbers per μl blood following the first vaccination, however, they hardly affected the responding CD4+ cTfh1 cell populations, although the response in MS-OCR patients was of slightly higher quality compared to those observed in HC and RA-MTX patients. The gene discussed is CD4; the disease is myeloid sarcoma.