Several kinds of literature have reported that proteolytic degradation of STEP occurs upon the synaptic NMDA receptor activation in Schizophrenia [30] or the suppression of brain‐derived neurotrophic factor (BDNF) in neuropsychiatric disorders [31], as well as that does in long‐term potentiation and learning [32]. The gene discussed is BDNF; the disease is schizophrenia.