Furthermore, the NCL/miR-221/NF-κB/DNMT1 axis promoting aggressive AML leukaemogenesis could be targeted by a nuclear localization signal (NLS) peptide-targeted gold nanoparticles (AuNPs) with coloaded anti-221 and AS1411 (NPsN-AS1411/a221), which could be used against AML without drug toxicity [114]. This evidence concerns the gene DNMT1 and acute myeloid leukemia.