Fatty acid-binding protein 4 (FABP4) has been reported to promote AML aggressiveness through enhanced DNMT1-dependent DNA methylation, FABP4 regulates DNMT1 expression through the IL-6/STAT3 axis, whereas DNMT1 controls FABP4 through VEGF signal pathway, which constitutes a feedback loop, in turn, affecting the process of leukaemia [73]. The gene discussed is DNMT1; the disease is acute myeloid leukemia.