Leptin levels were increased in the HSF group as compared to the control group and decreased in the HSF + γOz as compared to the HSF group. Adiponectin levels were increased in both HSF and HSF + γOz. Epididymal adipose tissue IL‐6, TNF‐α, and MCP‐1 were increased in the HSF group as compared to the control and HSF + γOz. PPAR‐γ expression in the adipose tissue was decreased in the HSF group and recovered in the HSF + γOz group. Authors advocate for the use of γOz as a natural supplement in COVID‐19. Here, LEP is linked to COVID-19.