Serum levels of chemerin and omentin were decreased in COVID‐19 in comparison to control patients. The comparison of COVID‐19 patients with different insulin sensitivity and control groups demonstrated that both patients with HOMA‐IR ≤ 3 or > 3 had significantly lower chemerin levels in comparison to the control group. Omentin was decreased only when comparing HOMA‐IR ≤ 3 COVID‐19 subgroup with healthy volunteers. This evidence concerns the gene INS and COVID-19.