CCL5 levels were higher in aged overweight and patients with obesity than normal‐weight patients, while MCP‐1 was lower in patients with obesity aged as compared to lean aged patients and lower in overweight young patients as compared to lean young patients. IL‐10 levels correlated negatively and EGF positively with BMI in young patients. TNF‐α and IL‐1RA correlated negatively and CCL5 correlated positively with BMI in aged patients. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.