After adjusting for age, body mass index, sex, hypertension, diabetes, smoking, TC, LDL-C, ApoA, and ApoB, S1PR5 was correlated with CHD (odds ratio 2.164, 95% CI: 1.670–2.804, P < 0.05), suggesting that higher S1PR5 expression may increase the risk of CHD. This evidence concerns the gene S1PR5 and Hypertension.