In wild-type TP53 tumor types, the expression level and transcriptional function of p53 protein are often negatively regulated by MDM2 and the homolog MDMX, resulting in inhibition of its tumor suppressor function (Ivanov et al., 2013; Wade et al., 2013; Meek, 2015; He et al., 2020). Here, TP53 is linked to neoplasm.