Both the activation of Nrf2 by the cyanoenone triterpenoids CDDO-ethyl amide/CDDO-trifluoroethyl amide and the disruption of Keap1-Nrf2 interaction by KEAP1-modifying small molecule MIND4-17 significantly enhance antioxidant functions of brain cells and ameliorate the behavioral phenotype in HD mouse (Stack et al., 2010; Quinti et al., 2017). This evidence concerns the gene KEAP1 and Huntington disease.