Furthermore, higher levels of baseline neurofilament light chain, 4-HNE, 8-oxo’2’-desoxyguanosine, and ferritin have been found to be independently associated with greater ALSFRS-r decline, suggesting the predictive value of these ferroptosis-related biomarkers for ALS diagnosis and prognosis (Devos et al., 2019). This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.