ALS is currently thought to be associated with gene mutation (e.g., SOD1 gene mutation), glutamate excitotoxicity, oxidative distress, immune disorders, mitochondrial dysfunction, and reduced axonal transport, but the exact etiology and pathogenesis remain unclear (Brown and Al-Chalabi, 2017; Hemerková and Vališ, 2021). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.