A poor correlation was determined between POCD and all AD models (APP/PS1 microarray: Figure 2A, Spearman’s R = −0.045; APP/PS1 RNA-seq: Figure 2B, Spearman’s R = −0.035; 5 × FAD RNA-seq: Figure 2C, Spearman’s R = −0.029; 3 × Tg-AD model: Figure 2D, Spearman’s R = 0.012). This evidence concerns the gene APP and Alzheimer disease.