As with pDC, dermal slanDC are reactive to self-RNA-LL37 complexes (42) and induce Th1/17 cells to produce IL-17, IL-22, TNF-α and IFN-γ (42, 43). In lesional skin of psoriasis patients, dermal slanDC express abundant IL-23-p19 and TNF-α (42, 47). The gene discussed is TNF; the disease is psoriasis.