IL-35, known as an anti-inflammatory cytokine (109, 110), decreased the total number of macrophages and ratio of M1/M2 macrophages in three psoriasis models: a human keratinocyte cell line (HaCaT), a keratin 14-VEGF A-transgenic mouse model, and an imiquimod-induced psoriasis mouse model (111). Here, KRT14 is linked to psoriasis.