The ERbB signaling, Alzheimer's disease, endocrine resistance, Fc epsilon RI signaling, prolactin signaling, and cholinergic synapse pathways had the highest relevance; the cholinergic synapse signaling pathway is the most clinically relevant pathway and may play key roles in many of the other signaling pathways. This evidence concerns the gene EGFR and early-onset autosomal dominant Alzheimer disease.