These pathways were divided into 11 categories based on signaling pathway functional clustering analysis, including AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, pathways in cancer, HIF-1 signaling pathway, hepatitis B, MAPK signaling pathway, lipid and atherosclerosis, fluid shear stress and atherosclerosis, bladder cancer, pancreatic cancer, and human cytomegalovirus infection. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.