These pathways were divided into 11 categories based on signaling pathway functional clustering analysis, including AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, pathways in cancer, HIF-1 signaling pathway, hepatitis B, MAPK signaling pathway, lipid and atherosclerosis, fluid shear stress and atherosclerosis, bladder cancer, pancreatic cancer, and human cytomegalovirus infection. The gene discussed is RENBP; the disease is urinary bladder cancer.