BHLHE41 and neoplasm: Hypoxia has been shown to be a potent inducer of tumor dormancy, for example, via the upregulation of the transcription factor NR2F1 and of the dormancy genes CDKN1B and DEC2 (also known as basic helix-loop-helix family member E41) in patient-derived and transgenic mouse models (Fluegen et al., 2017).