An experimental study (57) found that circadian misalignment led to decreases in leptin, the satiety hormone, and increases in ghrelin, the hunger hormone, only in women, while men showed increases in leptin and no changes in ghrelin, suggesting that altered RAR may predispose to obesity in women by increasing energy intake signalling. The gene discussed is GHRL; the disease is obesity due to melanocortin 4 receptor deficiency.