IL1B and cardiovascular disorder: It is mainly used for the treatment of cerebrovascular and cardiovascular diseases, including vascular dementia, ischemic cerebrovascular diseases, coronary heart diseases, etc. A study on the APP/PS1 double transgenic mouse model reported that NXTC could downregulate levels of Aβ, p-tau, apoptosis, and inflammatory cytokines, like IL-6, IL-1β and TNF-α through suppressing the toll like receptor 4/NF-κB/IL-1β signaling pathway.