Collectively, quercetin mainly exerts anti-AD effects through the following pathological mechanisms: 1) inhibition of Aβ production, aggregation and tau phosphorylation; 2) inhibition of the activity of AChE; 3) attenuation of oxidative stress and neuroinflammation (Paris et al., 2011; Qureshi et al., 2011; Abdalla et al., 2013; Sabogal-Guáqueta et al., 2015; Costa et al., 2016). Here, MAPT is linked to Alzheimer disease.