LIPT1 deficiency was reported in embryonic demise, early death or Leigh-like encephalopathy, such as early infantile epileptic encephalopathy, Leigh disease, secondary pyruvate dehydrogenase complex deficiency, fatal lactic acidosis (Soreze et al., 2013; Habarou et al., 2017; Stowe et al., 2018; Solmonson et al., 2022). The gene discussed is LIPT1; the disease is hyperinsulinemic hypoglycemia, familial, 4.