LIPT1 deficiency was reported in embryonic demise, early death or Leigh-like encephalopathy, such as early infantile epileptic encephalopathy, Leigh disease, secondary pyruvate dehydrogenase complex deficiency, fatal lactic acidosis (Soreze et al., 2013; Habarou et al., 2017; Stowe et al., 2018; Solmonson et al., 2022). Here, LIPT1 is linked to genetic developmental and epileptic encephalopathy.