Among these differentially expressed genes, 11 genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, MTF1, GLS, CDKN2A, SLC31A1, and ATP7B) were upregulated, while one gene (PDHB) were downregulated in melanoma (Figures 1A,B). The gene discussed is PDHB; the disease is melanoma.