IL1B and nonpapillary renal cell carcinoma: The central pro-inflammatory cytokine interleukin 1β (IL-1β) induces increased CXCL7 secretion by ccRCC cells, which can directly act on the surface receptor CXCR1/2 of ccRCC cells (Grépin et al., 2014); CXCL7 also acts paracrinely by promoting the proliferation of RCC cells, which in turn promotes further secretion of CXCL7 by peripheral blood monocytes in ccRCC (Kinouchi et al., 2017).