Further investigation of the mechanism by which NOX2 deficiency induces ALI/ARDS showed that NOX2 deficiency can activate platelets to increase their release of CXCL7, induce neutrophil migration to the alveolar lumen, and the formation of extracellular neutrophil traps (NET), leading to ALI/ARDS (Hook et al., 2019). The gene discussed is CYBB; the disease is acute respiratory distress syndrome.