The expression of CXCL7 and CXCR2 was found to be negatively correlated with disease-free survival (DFS) and OS in patients with liver metastatic CRC, suggesting that the CXCL7/CXCR2 signaling pathway may be involved in tumor recurrence and progression (Desurmont et al., 2015). The gene discussed is PPBP; the disease is neoplasm.