CXCR2 and intrahepatic cholangiocarcinoma: Sueoka et al. (Sueoka et al., 2014) also demonstrated that in the intrahepatic cholangiocarcinoma (ICC) cell lines RBE and SSP25, both CXCR2 siRNA and SB225002 significantly inhibited cell proliferation, migration, and invasion, while SB225002 also inhibited the growth of subcutaneous transplanted tumors in nude mice.