KCNJ11 and coronary artery disorder: rs5215 G/G (nucleotide change; G-A, amino acid change; Val337Ile) of the KCNJ11 gene, located at 11p15.1 and encoding the Kir6.2 subunit, causes valine-isoleucine substitution in exon 1,009 (ATC-GTC), and it is associated with a gain of function of the KATP channel, leading to vasodilation augmentation and shear stress reduction, which protects humans from lower coronary microvascular dysfunction, reducing the risk of ischemic heart disease in women (Severino et al., 2020).