In addition, in partially effective treatment regimens for patients with CHI, diazoxide opens the sarcKATP channel and inhibits insulin secretion, octreopeptide and long-acting somatostatin analogues act downstream of the KATP channel, inhibition of insulin secretion, subtotal pancreatectomy is used to reduce insulin production in focal and medically responsive non-focal cases (Rosenfeld et al., 2019). The gene discussed is INS; the disease is congenital isolated hyperinsulinism.