Several strains of Bifidobacterium adolescentis have been associated with a reduction in the expression of pro-inflammatory mediators such as IL-1β, TNF-α, and NF-κBp65; induction of T-helper 17 cells in humans and rodents; a significant reduction in ROS formation; regulation of the immune system; and driving the worsening of various conditions, including NAFLD-NASH progression, as supported by various pieces of evidence (Guo et al., 2019; Yu et al., 2019). This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.