PPARA and neoplasm: While, enriched pathways of vasoconstriction (vascular smooth muscle contraction, calcium signaling pathway, regulation of actin cytoskeleton), gene transcription (WNT Signaling Pathway), cell differentiation and apoptosis (MAPK signaling pathway), signal transduction (neuroactive ligand receptor interaction), cell adhesion (cell adhesion molecules CAMs, tight junction, gap junction) and lipid metabolism (PPAR signaling pathway, adipocytokine signaling pathway) were significantly downregulated in RASSF1A_met (+) tumor samples.