For example, the activating receptor NKp46 encoded by the natural cytotoxicity receptor 1 (NCR1) can be expressed in NK cells; this work limits tumor growth and metastasis by improving IFN-c release, while Runt-related transcription factor 3 (RUNX3) acts on the NCR1 promoter in NK cells and has demonstrable increases in function. This evidence concerns the gene RUNX3 and neoplasm.