The two SNPs (rs55829688 T > C and rs145204276 INS > DEL) in GAS5 have been shown to upregulate GAS5 expression by methylating its promoter, and then GAS5 binds miR-21 and miR‐2184 directly as a sponge, targeting PTEN, PDCD4, respectively, further inducing cell apoptosis in Prostate Cancer (PCa). The gene discussed is GAS5; the disease is prostate cancer.