Deletion of chromosome 17p [del(17p)] and TP53 mutation (TP53 mut) referred to as TP53 aberrations can be found in 8%–10% of previously untreated chronic lymphocytic leukaemia (CLL) patients and in up to 30%–40% of relapsed/refractory cases. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.