CD70 and neoplasm: Indeed, custom-built gene sets generated using the top 50 scoring differentially expressed genes from both B cell and CD70+ cell clusters found in our scRNA-seq data demonstrated comparable gene set enrichment analysis (GSEA) scores in bulk RMC tumor (normalized enrichment score (NES) = 2.382, p-value = 3.461e-8 and NES = 2.002, p-value = 2.798e-5 for gene sets of B and CD70+ cells, respectively), suggesting both types of CD70-expressing cells are overrepresented in malignant tissue.