CD70 and cancer: This claim is further substantiated by the observation that, among all cells, both UCA1+ EPCAM+ and CD70+ epithelial-like cells exclusively express MUC16 (adjusted p-values = 3.883e-132 and 9.967e-295, respectively) (Figure 2B and Supplementary Table 1) as a marker (also known as cancer antigen CA-125) associated with poor prognosis and advanced tumor stage in RCC (51, 53).