GPX4 and neoplasm: The mTORC signaling mechanism responsible for increasing GPX4 protein synthesis is dependent on SLC7A11-mediated cystine uptake from the extracellular environment, and in bulk RNA-seq data from (13) we found that the cystine transporter SLC7A11 is expressed at significantly higher levels in RMC tumor versus normal tissue (log2 fold change = 5.267, p-value = 5.386e-14).