Conversely, top-scoring differentially expressed genes of the high EPCAM cluster contain a large number of ribosomal protein genes, and genes aberrantly expressed in a selection of cancers [e.g., KRT18, adjusted p-value = 0.003 (47, 48)] including RCC [e.g., NAPSA, adjusted p-value = 4.038e-5 (49)] and RMC [POU5F1 also known as OCT3/4, adjusted p-value = 0.028 (50)] (Figure 2B and Supplementary Table 2). This evidence concerns the gene EPCAM and renal cell carcinoma.