GPNMB and nonpapillary renal cell carcinoma: Specifically, Figure 4A shows that the RMC Monocyte/Macrophage cell cluster was most enriched for a transcriptional profile associated with tumor associated macrophages (TAMs) expressing high levels of GPNMB that was shown to be associated with the anti-inflammatory M2 macrophage polarization signature found predominantly in untreated ccRCC (31).