Our previous results and literature data point on the possible ASIC1 and ENaC expressions in leukemia (15), glioma (16), melanoma (17), breast cancer (18), and pancreatic (19), lung (3), and hepatocellular carcinoma cells (20), where the ASIC1-containing channels participate in the regulation of cancer cell proliferation, migration, and invasion. The gene discussed is ASIC1; the disease is cancer.