To evaluate the physiological role of the different members of the DEG/ENaC family in the lung adenocarcinoma progression, we performed a comparative analysis of the expression of the ACCN2, ACCN1, ACCN3, ACCN4, SCNN1A, and SCNN1G genes in human lung adenocarcinoma tissues, tissues surrounding lung adenocarcinoma, and human healthy lung samples from TCGA LUAD and GTEX databases. This evidence concerns the gene ASIC4 and lung adenocarcinoma.