After adjusting for alcoholic liver disease, age, smoking status, drinking status, total bilirubin, neutrophil percentage, total hemoglobin, aspartate aminotransferase, serum sodium, albumin, lymphocyte percentage, creatinine, red blood cell, and white blood cell, the RCS model showed a non-linear relationship between INR classification and HE (Figure 2 non-linear test, χ2 = 30.940, Pnon−linearity < 0.001). The gene discussed is ALB; the disease is alcoholic liver diseases.