AKT1 and pulmonary arterial hypertension: Our data demonstrate that the pro-proliferative/pro-survival phenotype of PAVSMC in PAH is supported by glycolysis-dependent de novo lipid synthesis and suggest the potential role of Sirtuin 7 (SIRT7)- c-Jun N-terminal kinase (JNK)-Akt axis as a regulator of lipogenesis and a potential molecular target for anti-remodeling therapy.