CPT1A and pulmonary arterial hypertension: Interestingly, we detected no significant differences between non-diseased and PAH PAVSMC in protein levels of CPT1A (Figures 1A,E) and MLYCD (Supplementary Figure 1B), the regulatory enzymes in fatty acid β-oxidation and synthesis, in spite of previously reported up-regulation of CPT1A in smooth muscle cells in rats with monocrotaline-induced PH and protective effect of MLYCD deletion against development of hypoxia-induced PH in mice (28, 35).