Jeyalatha Mani et.al found that the expression of pro-inflammatory factors (IL-1β, IL-8, and IFN-γ) and TLRs (TLR-3/4/6) were significantly downregulated after CXL treatment in patients with fungal keratitis (32), suggesting that CXL may exerts an anti-inflammatory effect via TLRs pathway. The gene discussed is IFNG; the disease is fungal keratitis.