Conversely, FAT-WT patients had suppressive TME with high expression of CCL2, CXCL12, CXCL14, CD40, ENTPD1, TGFB1, and VEGF; these factors have been confirmed to promote angiogenesis, invasion, and metastasis of tumor cells (59–64). The gene discussed is CXCL12; the disease is neoplasm.