Then, the mutually exclusive or co-occurring genes analysis demonstrated that KMT2D (12.6%), ZFHX4 (12.9%), TTN (28.3%), MUC16 (19.3%), LRP1B (16.3%), CSMD3 (14.9%), PCLO (12.6%), CSMD1 (12.2%), HMCN1 (11.7%), PIK3CA (10.1%), FLG (12.9%), OBSCN (13.8%), ARID1A (16.1%), SYNE1 (16.1%), PCDH15 (11.5%), RYR2 (11.3%), SPTA1 (10.8%), and DNAH5 (10.8%) were co-occurring events of FAT mutations, and no mutually exclusive genes associated with FAT mutations were found in this study (Figure 3B). The gene discussed is PCDH15; the disease is energy intake.