Subsequently, immune-related gene expression profiles were analyzed in STAD patients with FAT mutations, the expression levels of genes related to activated immune cells (e.g., activated CD4 T cell and activated CD8 T cell) were significantly increased, and the expression levels of genes associated with suppressive immune cells (e.g., mast cell, plasmacytoid dendritic cell, and type 2 T helper cell) were remarkably reduced (Supplementary Figures 3A–E). The gene discussed is CD8A; the disease is energy intake.