We found that signature 1 (correlates with the age of cancer diagnosis), signature 6 (associated with defective DNA MMR), signature 15 (associated with defective DNA MMR), and signature 17 (the etiology remains unknown) were all identified regardless of the presence of FAT mutations, but signatures associated with DNA MMR were more abundant in the FAT-Mut group (Figure 3C). This evidence concerns the gene MRC1 and cancer.