ABHD5 and Dorfman-Chanarin disease: Mutations in the ABHD5 gene cause Chanarin-Dorfman syndrome (Lefevre et al., 2001) wherein the ability of ABHD5 to activate members of the PNPLA family is disrupted and results in disrupted lipid metabolism in numerous organs throughout the body (Hirabayashi et al., 2017; Yang et al., 2019).