In addition, we further analyzed the gene copy number alteration of USP45 in detail and the results showed that deletion of USP45 gene fragments was more common in DLBA, PRAD, and UVM, while the frequency of amplification of USP45 gene fragment was higher in OV, SARC and ACC (Figures 3A,H). Here, USP45 is linked to adrenal cortex carcinoma.