The results of pan-cancer analysis showed that in the TCGA database, relative to the normal group, the mRNA expression levels of USP45 were significantly upregulated in cholangio carcinoma (CHOL), colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), liver hepatocellular cancer (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), stomach adenocarcinoma (STAD), while downregulated in kidney chromophobe carcinoma (KICH), thyroid carcinoma (THCA) and uterine corpus endometrial carcinoma (UCEC). This evidence concerns the gene USP45 and uterine corpus endometrial carcinoma.