USP45 and neoplasm: USP45 and its top correlated genes were selected for drug sensitivity analysis, and the results (Supplementary Figure S8) showed that these genes with high expression are significantly associated with the resistance to a variety of anti-tumor drugs, such as Trametinib, selumetinib, Dabrafenib, Lapatinib, Erlotinib, Gefitinib, Docetaxel, and 17-AAG, indicating the oncogenic role of them.