TGFB1 and neoplasm: Similarly, the heat map of tumor-related pathways showed that cell cycle and DDR signatures were significantly decreased in TMEIG cluster B. Angio, transforming growth factor-beta (TGFβ), antigen processing machinery (APM), TGF-beta response signatures (TBRS) of fibroblasts (F-TBRS), and immune checkpoint signatures were increased in TMEIG cluster B as compared to that in cluster A (Supplementary Figure S3J).