The concentrations of MMP8, MMP9, TIMP1, and TIMP2 in patients with aortic coarctation have been reported to be higher than those in normal tissues, but MMP8 and MMP9 are much higher than TIMP1 and TIMP2, resulting in aortic coarctation disequilibrium. The gene discussed is TIMP2; the disease is aorta coarctation.